021-51111890
购物车（0）
sales@molnova.cn
GSK 690
CAS No. 2101305-84-2
GSK 690 ( GSK690 )
产品货号. M13334 CAS No. 2101305-84-2
GSK 690 是一种不可逆的、基于机制的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，IC50 为 77 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
|
| 50MG | ￥16038 | 有现货 |
|
| 100MG | ￥20250 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称GSK 690
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述GSK 690 是一种不可逆的、基于机制的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，IC50 为 77 uM。
-
产品描述GSK 690 is an irreversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1) with IC50 of 77 uM.
-
体外实验GSK690 (1-10μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells).GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1?μM GSK690 for RD cells) and 10?μM GSK690 for RH30 cells.GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest .
-
体内实验——
-
同义词GSK690
-
通路Chromatin/Epigenetic
-
靶点Histone Demethylase
-
受体Histone Demethylase
-
研究领域——
-
适应症——
化学信息
-
CAS Number2101305-84-2
-
分子量369.468
-
分子式C24H23N3O
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESN#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1
-
化学全称(R)-4-[5-(Pyrrolidin-3-ylmethoxy)-2-p-tolyl-pyridin-3-yl]-benzonitrile
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Mould DP, et al. J Med Chem. 2017 Sep 11. doi: 10.1021/acs.jmedchem.7b00462.
2. Mould DP, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4755-4759.
3. McGrath JP, et al. Cancer Res. 2016 Apr 1;76(7):1975-88.
